Thoughts
On tech, AI, business, and what actually works.
September 8, 2026
An AI-designed lung drug made six independent aging clocks run backward. But the study was a retrospective read of banked blood from 42 terminally ill patients, and the Phase III trial now running has no aging endpoint at all. What the rentosertib result actually shows.
August 10, 2026
DNA was isolated in 1869 from pus-soaked surgical bandages, proved to carry heredity in 1944 by a paper the field refused to believe, and finally given a shape in 1953 — a discovery whose credit is still being relitigated in the archives.
June 26, 2026
At Göbekli Tepe and the cluster of "Stone Hills" sites in southeastern Turkey, hunter-gatherers raised the world's oldest monuments some 11,500 years ago — before farming, pottery, or the wheel. The discoveries overturned a century-old assumption that agriculture had to come first, and suggest civilization may have begun not with the plow, but with the temple.
June 22, 2026
The protein-structure revolution that won AlphaFold a Nobel Prize has quietly split into three races — prediction, design, and medicine. A field guide to the top contenders (AlphaFold 3, Boltz, Chai, RFdiffusion, ESM3, Isomorphic Labs) and the one tension none of them has resolved: the benchmarks have never looked better, and not a single AI-designed drug has yet been approved.